Life at the Surface: More and more medical procedures involve either short or long term interactions between inherently incompatible materials, such as foreign inorganic devices, placed within a biological system. Whether it’s a catheter, a needle, a dental implant or a hip or knee replacement, the body is designed to recognize these objects as an invasion of foreign matter and mount a defense against it. The primary focus of Orthobond’s technology and research is to modify through chemistry the surface of medical implants and devices so as to render them biocompatible and to engender a desired biological response. The figure below outlines this basic paradigm.


The surfaces we are primarily interested in are those used in implants and ‘patient contact’ devices. Some of the most common are listed above. Orthobond has developed a proprietary linker technology which allows for a strong and stable connection between material surfaces and their in-vivo environments. These linkers serve as a platform to which a variety of custom chemistries can be applied. Judicious selection of end groups will determine which chemical and physical properties have been installed onto a surface. The customized properties of the new surface will engender the desired biological response from the system.