The Orthobond Strategy

Our strategy is to prevent initial attachment at the biomaterial surface.  One of the major difficulties in treating an infected device is reaching and killing organisms inside a biofilm.  The Orthobond approach is to kill bacteria at the stage of initial attachment which may effectively prevent subsequent biofilm production (biofilm lifecycle shown below).

 

technology

Major stages of biofilm formation.  Planktonic bacteria are more susceptible to antimicrobials.

 

Ortho-Samp

Example of an Orthobond SAMP.

 

Orthobond uses patented attachment technologies to bind antimicrobials to almost any biomaterial surface.  The process begins by building Self Assembled Monolayers of Phosphonates (SAMP) which are hydrolytically stable and biocompatible.  Functional groups at the distal end of the phosphonic acid are used to attach active molecules such as antimicrobials.